Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Mar 30;7:46. doi: 10.3389/fonc.2017.00046

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 Schrier, Trivedi and Deth.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Redox-dependent epigenetic regulation and oncogenesis. Left panel: transient Nrf2 activation is an important component of the adaptive metabolic responses to oxidative stressors, accompanied by epigenetic changes, which promote homeostatic restoration of redox equilibrium. Middle panel: multiple oxidative challenges increase the potential for DNA mutations, including mutations of growth factor signaling pathway components, which can lead to sustained Nrf2 activation, resulting in abnormal redox and epigenetic status. Right panel: methionine-independent and methionine-dependent states can alternatively emerge from oncogenesis, depending upon the level of MS activity, which is influenced by the ratio of cystine/cysteine uptake vs. transsulfuration. Abbreviations: GSH, glutathione; GSSG, glutathione disulfide; MS, methionine synthase; Nrf2, nuclear factor (erythroid-derived 2)-like 2.