FIGURE 1.

Schematic of the chick CaV2.2 α₁ subunit intracellular domains and the locations of the antigenic targets for the antibodies used in this study. C2Nt, NmidC2, and L45 antibodies are targeted against the C-terminal tail at different distances from the channel pore (diagram approximately to scale based on the polypeptide backbone) while Ab571 is targeted against a point approximate half way along the II–III loop. The previously described SV-binding region is located near the distal tip of the C-terminal tail (see text).