Table 2.

Mean subcortical volumes based on FIRST segmentation (comparisons across subgroups)

Brain structure (mean volume)	I Chemotherapy group (n = 22)		II Chemo- and radiotherapy group (n = 11)		III ALL control group (n = 12)		I vs III (t test)		II vs III (t test)		I vs II (t test)
	Volumes (mm3)
	Mean	SD	Mean	SD	Mean	SD	t	p	t	p	t	p
Thalamus	7093	710	6710	279	7104	664	0.657	0.519	0.750	0.466	1.515	0.140
Hippocampus	4067	391	3417	220	4059	511	0.611	0.541	3.321	0.004	4.954	<0.001
Amygdala	1482	181	1402	137	1658	295	1.198	0.247	1.796	0.090	1.261	0.217
Caudate nucleus	3842	439	3796	357	4433	340	2.767	0.010	2.828	0.013	0.194	0.847
Putamen	5887	518	6015	500	5908	595	0.289	0.771	0.728	0.476	0.631	0.532
Globus pallidus	1728	235	1673	156	1957	146	1.818	0.082	3.189	0.005	1.041	0.306
Gray matter	658872	60581	680733	51924	668637	59581	0.386	0.703	0.398	0.696	0.814	0.424
White matter	499963	42262	497747	43763	524515	49034	1.312	0.201	1.062	0.306	0.113	0.911
Brain ventricles	7906	1421	7488	1470	9625	2599	4.322	0.001	3.792	0.001	0.788	0.437

All data given is raw scores (absolute volumes of brain structures)

Values in italics has statistical significance set at p < 0.05