Table 4.
KEGG pathways target of miRNAs potentially deregulated in AMD.
| A. miR-27a, miR-146a, miR-155 | p-value | #genes |
|---|---|---|
| TGF-beta signaling pathway | 1.31E-11 | 44 |
| Prion diseases | 2.90E-11 | 14 |
| Hippo signaling pathway | 2.53E-7 | 60 |
| AMPK signaling pathway | 1.16E-6 | 62 |
| Fatty acid biosynthesis | 1.50E-6 | 3 |
| Fatty acid elongation | 7.45E-6 | 9 |
| Lysine degradation | 7.73E-6 | 22 |
| Neurotrophin signaling pathway | 8.25E-6 | 58 |
| mTOR signaling pathway | 2.61E-5 | 35 |
| Protein processing in endoplasmic reticulum | 2.65E-5 | 73 |
| TNF signaling pathway | 3.20E-5 | 51 |
| Fatty acid metabolism | 5.17E-5 | 16 |
| Signaling pathways regulating pluripotency of stem cells | 5.17E-5 | 62 |
| FoxO signaling pathway | 5.78E-5 | 60 |
| Thyroid hormone signaling pathway | 6.42E-5 | 48 |
| Adherens junction | 1.61E-4 | 36 |
| Ubiquitin mediated proteolysis | 3.12E-4 | 62 |
| Central carbon metabolism in cancer | 3.12E-4 | 30 |
| HIF-1 signaling pathway | 9.92E-4 | 51 |
| ErbB signaling pathway | 2.38E-3 | 39 |
| Sphingolipid signaling pathway | 2.67E-3 | 48 |
| Focal adhesion | 3.26E-3 | 81 |
| Insulin signaling pathway | 4.31E-3 | 58 |
| NF-kappa B signaling pathway | 4.31E-3 | 32 |
| Apoptosis | 4.68E-3 | 38 |
| Cell cycle | 9.58E-3 | 50 |
| PI3K-Akt signaling pathway | 1.18E-2 | 121 |
| ECM-receptor interaction | 1.68E-2 | 26 |
| p53signaling pathway | 2.16E-2 | 30 |
| Toll-like receptor signaling pathway | 2.33E-2 | 39 |
| Axon guidance | 3.13E-2 | 43 |
| RNA transport | 3.38E-2 | 62 |
| Endocytosis | 4.53E-2 | 72 |
| B. miR-9, miR-23a, miR-27a, miR-34a, miR-126,miR-146a, miR-155 | p-value | #genes |
| Fatty acid metabolism | 3.15E-1 | 30 |
| Fatty acid elongation | 8.96E-3 | 14 |
| Fatty acid degradation | 2.02E-4 | 24 |
| Adherens junction | 3.86E-3 | 53 |
| TGF-beta signaling pathway | 4.74E-4 | 56 |
| Fatty acid biosynthesis | 8.23E-4 | 7 |
| Thyroid hormone signaling pathway | 9.39E-3 | 84 |
| Protein processing in endoplasmic reticulum | 9.39E-3 | 114 |
| Prion diseases | 1.09E-5 | 21 |
| p53 signaling pathway | 8.77E-5 | 54 |
| mTOR signaling pathway | 2.91E-6 | 47 |
| Hippo signaling pathway | 4.40E-6 | 90 |
| Neurotrophin signaling pathway | 5.23E-6 | 82 |
| TNF signaling pathway | 7.93E-5 | 74 |
| Cell cycle | 1.18E-4 | 83 |
| Endocytosis | 1.28E-4 | 130 |
| Signaling pathways regulating pluripotency of stem cells | 1.58E-4 | 90 |
| Sphingolipid signaling pathway | 4.27E-4 | 76 |
| ErbB signaling pathway | 5.24E-4 | 62 |
| Lysine degradation | 7.50E-4 | 31 |
| Axon guidance | 8.49E-4 | 78 |
| Estrogen signaling pathway | 8.68E-4 | 63 |
| Insulin signaling pathway | 1.04E-3 | 91 |
| Focal adhesion | 1.07E-3 | 128 |
| FoxO signaling pathway | 1.06E-3 | 88 |
| Ubiquitin mediated proteolysis | 2.08E-3 | 89 |
| HIF-1 signaling pathway | 2.21E-3 | 72 |
| Glycosaminoglycan biosynthesis - keratansulfate | 2.64E-3 | 11 |
| Regulation of actin cytoskeleton | 4.51E-3 | 123 |
| Apoptosis | 5.05E-3 | 57 |
| AMPK signaling pathway | 7.36E-3 | 80 |
| N-Glycan biosynthesis | 1.41E-2 | 30 |
| RNA degradation | 2.41E-2 | 49 |
| Fc gamma R-mediated phagocytosis | 2.69E-2 | 55 |
| NF-kappa B signaling pathway | 2.69E-2 | 52 |
| VEGF signaling pathway | 3.02E-2 | 40 |
| C. miR-155 | p-value | #genes |
| TGF-beta signaling pathway | 4.69E-4 | 11 |
| FoxO signaling pathway | 4.69E-4 | 26 |
| Apoptosis | 1.29E-3 | 20 |
| Steroid biosynthesis | 2.13E-3 | 4 |
| NF-kappa B signaling pathway | 2.13E-3 | 17 |
| TNF signaling pathway | 2.14E-3 | 22 |
| Inflammatory bowel disease (IBD) | 4.66E-3 | 13 |
| Adherens junction | 9.67E-3 | 14 |
| Fatty acid elongation | 1.13E-2 | 4 |
| Signaling pathways regulating pluripotency of stem cells | 1.19E-2 | 25 |