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. 2017 Mar 30;8:195. doi: 10.3389/fphys.2017.00195

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Copyright © 2017 Bai, Yin, Wang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Requirements for delayed afterdepolarizations (DADs) to produce a premature ventricular complex (PVC) in the 1D cable in which a central region of contiguous myocytes exhibiting DADs was surrounded by normal cells. (A) No PVC produced due to subthreshold DADs in the central region. (B) No PVC generated, though cells in the central region exhibiting suprathreshold DAD but the length of the region is under a critical value (e.g., 24 cells). (C) A PVC generated as the length of the region exhibiting suprathreshold DAD is over a critical value (e.g., 25 cells).