FIGURE 1.

Experimental design. Animals either received vehicle alone, CPT-11 alone, or CPT-11 and HQD. The toxicity model was constructed by treatment of animals with CPT-11 at 150 mg/kg by intravenous injection (i.v.) once a day for two consecutive days (day 1–2). HQD (10 g/kg) was given orally twice a day for 6 days beginning on day 0 (day 0–5). The mortality, weight loss and food intake of animals were monitored daily. The rats were finally euthanized on day 5. Serum and tissues (liver, jejunum, ileum, cecum, colon, and rectum) were collected for preparation and analysis. The dashed part is completed in the pilot study.