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. 2017 Mar 30;8:162. doi: 10.3389/fphar.2017.00162

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Copyright © 2017 Festa, De Marino, Carino, Sepe, Marchianò, Cipriani, Di Leva, Limongelli, Monti, Capolupo, Distrutti, Fiorucci and Zampella.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Preparation of chemical library. Reagent and conditions: (a) MsCl, TEA; ethyl ether, –10°C; (b) NaN₃, DMSO, DMF, 150°C; (c) NaOMe, MeOH, r.t.; (d) LiBH₄, MeOH dry, THF, 0°C; (e) NH₄Cl, Zn, MeOH:H₂O (1:0.1); (f) NaOH 5% in MeOH/H₂O 1:1 v/v, reflux; (g) pTsCl, pyridine, r.t.; (h) CH₃COOK, DMF:H₂O (5:1), reflux.