Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Mar 30;8:162. doi: 10.3389/fphar.2017.00162

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 Festa, De Marino, Carino, Sepe, Marchianò, Cipriani, Di Leva, Limongelli, Monti, Capolupo, Distrutti, Fiorucci and Zampella.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Effects of compound 2 after mice administration on bile acid pool and evaluation of metabolic profile. (A–C) Effects of compound 2 administration on levels of unconjugated and tauro-conjugated bile acids in plasma (A,B, respectively) and gallbladder (C). (D,E) Plasmatic and gallbladder levels of 2 and 2a. Results are the mean ± SE of 5 mice per group. ^∗p < 0.05 versus naive mice, #p < 0.05 versus 2 treated mice. (F) Preparation of compound 2a. (G) In vitro evaluation of 2a on FXR. Activity was measured in HepG2 cells co-transfected with pSG5-FXR, pSG5-RXR, pGL4.70 Renilla and p(hsp27) TKLUC vectors. Twenty-four hours post transfection cells were stimulated with increasing concentrations of 2a from 10 nM to 25 μM. Results are expressed as mean ± standard error.