Table 2.

Unadjusted means and adjusted differences in hemostatic biomarkers between users of CEE and E2.

		Unadjusted means (SD)		Adjusted absolute difference between CEE users and E2 users *
		E2 users (n=93)	CEE users (n=48)	E2 users (n=93)	CEE users (n=48)	P-value
Thrombin Generation	Peak value (nM)	262.5 (62.1)	316.0 (85.8)	Reference	+49.8 (21.0 to 78.6)	0.001
	ETP (nMxMin)	1183.5 (255.7)	1337.0 (361.1)	Reference	+175.0 (54.4 to 295.7)	0.005
	Lag-time (min)	2.1 (0.34)	2.0 (0.89)	Reference	−0.01 (−.26 to 0.25)	0.97
	Time to peak (min)	4.1 (0.7)	3.8 (1.1)	Reference	−0.2 (−0.5 to 0.2)	0.27
Factor VII (%)		136.0 % (38.8)	135.3 % (36.3)	Reference	−8.7 (−23.0 to 5.6)	0.23
Antithrombin (%)		104.5 % (12.7)	102.8 % (17.5)	Reference	−2.7 (−8.4 to 3.0)	0.35
Total protein S (%)		105.9 % (18.2)	92.3 % (16.6)	Reference	−13.4 (−19.8 to −6.9)	<0.001

^*Adjusted for age, race, BMI, cancer, FVL, use of statins, diabetes, use/dose of progestogen, dose of estrogen

Missing values: Factor VII (n=7), Antithrombin (n=10), Protein S (n=1).

ETP= endogenous thrombin potential