Table 4.
Unadjusted means and adjusted differences in hemostatic biomarkers between non-HT users and users of CEE or users of E2.
| Unadjusted means (SD) | Adjusted absolute difference between E2 or CEE users and non-users * | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Non HT users (n=141) | E2 users (n=93) | CEE users (n=48) | Non HT users (n=141) | E2 users (n=93) | P-value | CEE users (n=48) | P-value | ||
| Thrombin generation | Peak value (nM) | 262.2 (56.6) | 262.5 (62.1) | 316.0 (85.8) | Ref. | +2.4 (−12.9 to 17.7) | 0.76 | +56.4 (30.3 to 82.5) | <0.001 |
| ETP (nMxMin) | 1212.7 (265.3) | 1183.5 (255.7) | 1337.0 (361.1) | Ref. | −28.4 (−95.3 to 38.6) | 0.41 | +137.5 (26.3 to 248.7) | 0.016 | |
| Lag-time (min) | 2.3 (0.6) | 2.1 (0.3) | 2.0 (0.9) | Ref. | −0.2 (−0.3 to −0.1) | 0.004 | −0.2 (−0.5 to 0.0) | 0.09 | |
| Time to peak (min) | 4.4 (0.9) | 4.1 (0.7) | 3.8 (1.1) | Ref. | − 0.3 (−0.5 to −0.1) | 0.004 | −0.6 (−0.9 to −0.2) | 0.001 | |
| Factor VII (%) | 131.1 (35.7) | 136.0 (38.8) | 135.9 (36.3) | Ref. | +8.0 (−2.2 to 18.2) | 0.12 | +5.8 (−6.3 to 17.8) | 0.35 | |
| Antithrombin (%) | 106.5 (13.6) | 104.5 (12.7) | 102.8 (17.5) | Ref. | −1.9 (−5.6 to 1.8) | 0.32 | −4.1 (−9.4 to 1.3) | 0.14 | |
| Total protein S (%) | 109.4 (18.7) | 105.9 (18.2) | 92.3 (16.6) | Ref. | −2.6 (−7.3 to 2.2) | 0.29 | −16.1 (−21.6 to −10.7) | <0.001 | |
*
Adjusted for age, race, BMI, cancer, FVL, use of statins, diabetes.
Missing values: Factor VII (n=7), Antithrombin (n=10), Protein S (n=1).
ETP= endogenous thrombin potential