Figure 7. Three‐step strategy for the treatment of NAFLD and associated disorders.

Based on our results, we postulate a potential treatment strategy for NAFLD patients based on increased oxidation of fat and increased synthesis of GSH. A cocktail can be supplemented to NAFLD patients to boost these metabolic processes and to decrease the hepatic lipid accumulation. NR can be supplemented to boost the oxidation of the fat in the mitochondria by generating NAD⁺. Serine and NAC can be included in the cocktail to boost the level of GSH which is required for preventing the accumulation of incomplete products of fatty acids oxidation. l‐carnitine can also be added to the cocktail to boost the fatty acid uptake into mitochondria.