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. 2017 Jan 12;7(1):7. doi: 10.3390/bios7010007

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Protection of SERS-based immunoassay. (A) Time dependence of the signal intensity for the 4-nitrobenzenethiol used as a Raman reporter molecule. Raman peak at 1336 cm⁻¹ corresponding to NO₂ symmetric stretch vibration deteriorates with time under laser light exposure (spectra shifted for clarity). (B) A comparative graph showing the intensity of 1336 cm⁻¹ band with time for different protective strategies: (I) no protection, (II) a layer of PDMS, (III) PEG-1000 Da coadsorbed with RRMs on Au nanotag, (IV) graphene monolayer applied on top of immunoassay addresses. (C) Comparison of intensities at 150 s time for protection shown in (B).