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Tetracycline inhibits Loxosceles venom and SMase D induced MMPs. HK-2 cell cultures (5 × 104 cells) were incubated with venom (V) (B) or SMase D (S) (C) from L. intermedia (5 µg/200 µL total volume), and treated or not with tetracycline (T) [20 µg/mL]. Supernatants of the HK-2 cells were collected after 48 h of incubation and submitted to zymography (A, B) followed by densitometry analyses (C–F). Significant differences (*) p < 0.05.
