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Side-by-side comparison of the mouse bioassay and the mass spectrometry method for BoNT/A in human serum.
| BoNT Type A (mLD50) | MALDI-TOF MS | Mouse Bioassay | ||
|---|---|---|---|---|
| Replicate 1 | Replicate 2 | Mouse 1 | Mouse 2 | |
| 72 | Positive | Positive | Expired | Expired |
| 36 | Positive | Positive | Expired | Expired |
| 18 | Positive | Positive | Expired | Expired |
| 1.8 | Negative | Negative | Expired | Survived |
| 0.18 | Negative | Negative | Survived | Survived |
| 0.018 | Negative | Negative | Survived | Survived |
| Negative | Negative | Negative | Survived | Survived |
