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Side-by-side comparison of the mouse bioassay and the mass spectrometry method for BoNT/B in human serum.
| BoNT Type B (mLD50) | MALDI-TOF MS | Mouse Bioassay | ||
|---|---|---|---|---|
| Replicate 1 | Replicate 2 | Mouse 1 | Mouse 2 | |
| 100 | Positive | Positive | Expired | Expired |
| 50 | Positive | Positive | Expired | Expired |
| 25 | Positive | Positive | Expired | Expired |
| 2.5 | Negative | Negative | Survived | Survived |
| 0.25 | Negative | Negative | Survived | Survived |
| 0.025 | Negative | Negative | Survived | Survived |
| Negative | Negative | Negative | Survived | Survived |
