Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Double-stranded breaks (DSBs) induce endogenous DNA repair mechanisms. DSBs can be repaired by non-homologous end joining (NHEJ) or homology-directed repair (HDR). NHEJ often leads to deleterious insertions or deletions (indels), while HDR leads to high-fidelity DNA repair using the homologous chromosome or exogenously introduced DNA as a template.
