Table 3.

Usage of HbV as a CO carrier for anti-inflammatory and anti-oxidative effect.

Application	Animal Species	Brief Description of Main Results	Reference
Hemorrhagic shock	Wistar rats	Hemorrhagic shocked rats were resuscitated with CO-HbV suspended in HSA. AST and ALT levels were reduced as compared to O2-HbV injection	[48]
Pulmonary fibrosis	Sea-ICR mice	Bleomycin-induced pulmonary fibrosis mice that received CO-HbV showed suppression of progression of fibrosis and improved respiratory function	[49]
Colitis	Sea-ICR mice	Dextran sulfate sodium-induced colitis model mice receiving CO-HbV improved colitis symptoms, colonic histopathological changes and the duration of survival compared to both saline and O2-HbV administration	[50]
Pancreatitis	BALB/cN mice	Pancreatitis model mice were prepared with a choline-deficient ethionine-supplemented diet. CO-HbV inhibited the production of systemic proinflammatory cytokines, neutrophil infiltration, and oxidative injuries	[51]