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. 2017 Feb 7;6(1):5. doi: 10.3390/pathogens6010005

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of neurotrophic factor (NTF) deprivation on HSV reactivation in adult SCG neurons. Nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) deprivation induced reactivation of HSV1, but not HSV2, shown by significantly increased viral DNA copies 24 h after removal of individual NTFs and addition of their respective neutralizing antibodies after 7 days of acyclovir (ACV)-induced latency, compared to control neurons maintained in all three neurotrophic factors (p = 0.005 and 0.01).