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. 2017 Feb 7;6(1):5. doi: 10.3390/pathogens6010005

Figure 3.

Figure 3

Effect of NTF deprivation on reactivation in adult sensory neurons. Deprivation of NTN induced reactivation of HSV1, either alone (p = 0.034) or in combination with GDNF deprivation (p = 0.012), compared to control neurons maintained in all three NTFs, shown by significantly increased HSV copy numbers 24 h after withdrawal of NTFs and addition of antibodies. There was no significant difference between NTN- and GDNF-/NTN- for HSV1. Deprivation of GDNF induced reactivation of HSV2, either alone (p = 0.042) or in combination with NGF (p = 0.040) or NTN (p = 0.015) deprivation, compared to controls.