Figure 1.

Schematic metabolic model showing important pathways after proliferation of Streptococcus suis serotype 2 in porcine blood (A) and cerebrospinal fluid (CSF) (B). This model is based on the genome annotation of S. suis serotype 2 strain P1/7. Important differentially expressed genes found in our study are depicted by colored boxes. Red boxes and green boxes indicate lower- and higher-expressed genes compared to growth in Todd-Hewitt broth (THB), respectively; black boxes indicate that no differential expression was observed. Metabolic pathways are highlighted in different colors and are simplified: dark green, Embden–Meyerhof–Parnas (EMP) pathway (glycolysis); blue, pentose phosphate pathway (PPP); light purple, glycogen metabolism; red, pyruvate metabolism; brown, incomplete tricarboxylic acid (TCA) cycle; orange, Leloir pathway; yellow, pyrimidine metabolism; light green, purine metabolism; pink, amino acid metabolism. For additional information on gene annotations and metabolite abbreviations used, see Supplementary Table S5.