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. 2017 Mar 30;7:45527. doi: 10.1038/srep45527

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Copyright © 2017, The Author(s)

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(A) Significant decrease in the levels of two amino sugar metabolites at 1 hr and 4 hr by colistin, doripenem and the combination, and perturbation of the cell envelope biosynthesis (peptidoglycan and lipopolysaccharide biosynthesis) in A. baumannii ATCC 19606. UDP-N-acetyl-D-glucosamine (UDP-GlcNAc) is a key precursor metabolite for LPS and peptidoglycan biosynthesis. (B) Levels of two key metabolites of peptidoglycan biosynthesis significantly decreased after treatment with doripenem alone at 4 hr. The combination of colistin and doripenem also significantly decreased UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine (>2.0-log₂-fold) at 4 hr. The blue boxes in the flow charts indicate the metabolites that were significantly decreased. The red boxes indicate the metabolites that were not significantly changed. Box plots indicate upper and lower quartiles (top and bottom of box); median (line within box); and the spread of data that are not outliers (whiskers). *≥1.5-log₂-fold, p ≤ 0.05, FDR ≤ 0.1 (one-way ANOVA).