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. 2017 Mar 30;7:45540. doi: 10.1038/srep45540

Figure 4. Behavioural and histopathological changes after treatment with DDBM.

Figure 4

(A) The animals exposed to ECS administration showed varied durations of seizures (6.3 ± 1.8, 69.0 ± 18.1 and 122 ± 7.5 sec for ECS1, ECS2 and ECS3 respectively). Treatment with DDBM showed significant reduction in the duration of seizures of ECS2 (7.1 ± 1.3 sec; p < 0.01) and ECS3 (8.7 ± 1.5 sec; p < 0.001) while the significant effect was not seen in the duration of seizures of ECS1 (2.1 ± 0.3; p > 0.05). The data of this experiment showed clearly that the treatment with DDBM attenuated the ECS-induced seizure durations particularly those induced by ECS2 & ECS3 (Two-way ANOVA with Bonferroni post-tests). (B) The number of neurons present in the various hippocampal regions of DDBM- treated and non-treated epileptic rats. In the rats treated with the compound followed by ECS, there were significant differences in the number of neurons present in the CA1 (p < 0.01), CA3 (p < 0.05), and DG (p < 0.01) hippocampal fields, compared to the ECS group. Moreover, significant differences have been observed in this case between the hippocampal regions in the shame and ECS group (CA1, p < 0.01; CA3, p < 0.05; and DG, p < 0.001, One-Way ANOVA with Tukey post test).