KL001. |
This molecule stabilises CLOCK protein in vitro, in this way increasing the length of the clock period. KL001 also decreases hepatic glucose production [171]. |
SR9009 and SR9011. |
These molecules are REV-ERBα agonists, and were shown to decrease Cry2 rhythms, to increase Per2 rhythms and to shift Bmal1 ones. SR009 was also effective in decreasing adiposity and in improving dyslipidaemia and hyperglycaemia in a mouse obesity model [161]. |
Longdaysin. |
This molecule was shown to increase circadian period both in vitro and in vivo by inducing PER1 degradation through the modulation of several kinases, and in particular CKIα [172]. |