Table 1.
Biochemical parameters during the follow-up according to trajectory groups
| ‘Rapid PTH drop’ group N=34 (12.7%) |
“Gradual PTH decrease” group N=98 (36.4%) |
‘Slow PTH decrease with high phosphate’ group N=105 (39.0%) |
‘Uncontrolled SHPT’ group N=32 (11.9%) |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Mean | SD | N | Mean | SD | N | Mean | SD | N | Mean | SD | p Value* | |
| Serum 25-OH vitamin D level (ng/mL) | |||||||||||||
| At baseline | 31 | 17.2 | 11.8 | 67 | 18.7 | 12.2 | 68 | 20.1 | 16.2 | 22 | 22.5 | 13.2 | 0.53 |
| At 3 months | 18 | 27.2 | 17.2 | 30 | 20.4 | 12.0 | 36 | 23.4 | 15.1 | 14 | 24.5 | 13.4 | 0.45 |
| At 6 months | 15 | 31.3 | 21.0 | 37 | 21.9 | 11.4 | 38 | 22.1 | 15.0 | 9 | 27.6 | 15.5 | 0.15 |
| At 9 months | 15 | 30.0 | 14.4 | 34 | 22.7 | 15.2 | 33 | 24.5 | 15.3 | 13 | 21.4 | 8.1 | 0.36 |
| At 12 months | 15 | 30.5 | 14.4 | 37 | 26.8 | 14.5 | 37 | 27.7 | 34.6 | 15 | 23.9 | 13.8 | 0.89 |
| At 15 months | 15 | 23.0 | 11.6 | 34 | 24.4 | 13.5 | 26 | 28.1 | 15.9 | 10 | 17.7 | 8.7 | 0.22 |
| At 18 months | 15 | 30.5 | 16.7 | 26 | 27.0 | 18.2 | 36 | 28.3 | 14.2 | 11 | 26.3 | 16.0 | 0.90 |
| At 21 months | 11 | 32.8 | 11.1 | 33 | 27.1 | 16.6 | 29 | 28.2 | 14.8 | 15 | 21.1 | 10.6 | 0.23 |
| At 24 months | 10 | 36.9 | 17.1 | 31 | 26.5 | 18.0 | 24 | 25.8 | 13.9 | 13 | 24.1 | 12.0 | 0.22 |
| Serum alkaline phosphatase level (UI/L) | |||||||||||||
| At baseline | 34 | 94.5 | 36.1 | 96 | 102.0 | 46.1 | 104 | 98.3 | 44.5 | 31 | 162.1 | 199.2 | <0.001 |
| At 3 months | 31 | 101.1 | 48.6 | 85 | 98.0 | 41.7 | 96 | 101.3 | 48.0 | 28 | 176.8 | 185.4 | <0.0001 |
| At 6 months | 30 | 89.1 | 35.4 | 82 | 97.6 | 36.0 | 97 | 103.1 | 48.8 | 26 | 184.5 | 149.0 | <0.0001 |
| At 9 months | 29 | 79.4 | 32.0 | 76 | 97.9 | 41.0 | 94 | 100.4 | 40.3 | 25 | 200.2 | 169.1 | <0.0001 |
| At 12 months | 27 | 78.1 | 27.6 | 76 | 96.9 | 50.1 | 86 | 102.9 | 43.1 | 29 | 168.3 | <0.0001 | |
| At 15 months | 25 | 85.2 | 39.9 | 65 | 101.7 | 74.0 | 79 | 107.7 | 58.6 | 29 | 165.7 | 134.3 | 0.0001 |
| At 18 months | 24 | 93.3 | 44.3 | 67 | 96.2 | 38.9 | 69 | 103.5 | 53.9 | 25 | 158.3 | 117.7 | <0.001 |
| At 21 months | 21 | 82.0 | 33.8 | 62 | 94.9 | 36.4 | 68 | 103.3 | 48.2 | 25 | 151.1 | 81.3 | <0.0001 |
| At 24 months | 20 | 86.8 | 47.1 | 60 | 92.7 | 35.0 | 58 | 105.9 | 49.7 | 22 | 184.5 | 182.0 | <0.0001 |
| Serum albumin level (g/L) | |||||||||||||
| At baseline | 33 | 35.4 | 5.6 | 92 | 36.4 | 4.3 | 102 | 35.8 | 4.5 | 31 | 37.4 | 4.4 | 0.28 |
| At 3 months | 28 | 35.4 | 3.7 | 80 | 35.5 | 5.0 | 88 | 35.9 | 4.8 | 27 | 37.1 | 4.9 | 0.47 |
| At 6 months | 31 | 35.8 | 5.0 | 74 | 35.6 | 5.3 | 88 | 36.9 | 4.8 | 25 | 37.2 | 5.4 | 0.28 |
| At 9 months | 26 | 34.5 | 5.3 | 70 | 35.2 | 5.0 | 85 | 36.5 | 4.7 | 29 | 38.2 | 4.7 | 0.01 |
| At 12 months | 26 | 33.8 | 5.5 | 68 | 34.9 | 5.4 | 77 | 35.4 | 5.0 | 25 | 37.4 | 5.4 | 0.10 |
| At 15 months | 23 | 33.4 | 6.5 | 61 | 35.0 | 6.0 | 73 | 35.6 | 4.8 | 27 | 37.6 | 5.5 | 0.06 |
| At 18 months | 24 | 32.9 | 6.9 | 61 | 35.4 | 5.7 | 70 | 35.8 | 5.7 | 25 | 36.5 | 5.5 | 0.14 |
| At 21 months | 19 | 33.5 | 6.0 | 59 | 35.6 | 4.7 | 70 | 36.1 | 4.7 | 27 | 37.6 | 5.0 | 0.04 |
| At 24 months | 17 | 35.1 | 3.6 | 54 | 35.6 | 5.1 | 65 | 36.2 | 5.4 | 21 | 38.1 | 3.3 | 0.18 |
| Serum bicarbonate level (mmol/L) | |||||||||||||
| At baseline | 34 | 22.4 | 3.3 | 98 | 22.2 | 3.6 | 103 | 22.1 | 3.3 | 32 | 22.1 | 4.3 | 0.97 |
| At 3 months | 33 | 23.3 | 3.2 | 91 | 23.2 | 3.4 | 100 | 22.4 | 3.4 | 29 | 21.1 | 3.8 | 0.02 |
| At 6 months | 32 | 23.1 | 2.6 | 87 | 23.4 | 3.7 | 97 | 22.6 | 3.9 | 30 | 22.1 | 2.7 | 0.26 |
| At 9 months | 29 | 23.9 | 3.1 | 84 | 23.3 | 3.4 | 96 | 22.8 | 3.5 | 27 | 22.8 | 2.6 | 0.36 |
| At 12 months | 27 | 23.7 | 3.1 | 80 | 22.8 | 3.1 | 88 | 23.1 | 4.0 | 25 | 22.0 | 3.2 | 0.31 |
| At 15 months | 26 | 23.7 | 3.4 | 72 | 23.4 | 3.8 | 79 | 22.9 | 3.6 | 27 | 22.8 | 3.2 | 0.66 |
| At 18 months | 26 | 24.2 | 3.1 | 72 | 23.3 | 3.7 | 80 | 23.1 | 4.0 | 27 | 22.0 | 3.1 | 0.16 |
| At 21 months | 23 | 24.1 | 3.2 | 68 | 23.9 | 3.6 | 76 | 23.2 | 3.2 | 27 | 22.2 | 3.2 | 0.10 |
| At 24 months | 21 | 24.1 | 2.6 | 63 | 24.3 | 3.8 | 73 | 23.5 | 3.5 | 26 | 22.6 | 3.0 | 0.15 |
Bold indicates statistical significance, p<0.05.
*Analysis of variance or Wilcoxon's test used to compare continuous variables.
PTH, parathyroid hormone; SHPT, secondary hyperparathyroidism.