Table 2.
Baseline characteristics of patients according to trajectory groups
| ‘Rapid PTH drop’ group N=34 (12.7%) |
‘Gradual PTH decrease’ group N=98 (36.4%) |
‘Slow PTH decrease with high phosphate’ group N=105 (39.0%) |
‘Uncontrolled SHPT’ group N=32 (11.9%) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | %/ Mean | SD | N | %/ Mean | SD | N | %/ Mean | SD | N | %/ Mean | SD | p Value* | |
| Sociodemographic data | |||||||||||||
| Age at baseline | 34 | 68.8 | 14.6 | 98 | 68.5 | 13.6 | 105 | 67.2 | 14.9 | 32 | 54.1 | 19.4 | <0.0001 |
| Gender male | 22 | 64.7 | 59 | 60.2 | 56 | 53.3 | 20 | 62.5 | 0.57 | ||||
| BMI | 34 | 28.3 | 6.9 | 98 | 28.0 | 7.2 | 105 | 27.4 | 6.3 | 32 | 26.5 | 6.3 | 0.66 |
| BMI>30 kg/m2 | 14 | 41.2 | 33 | 33.7 | 33 | 31.4 | 6 | 18.8 | 0.26 | ||||
| Former or active tobacco consumption | 8 | 23.5 | 26 | 26.5 | 33 | 31.4 | 10 | 31.3 | 0.76 | ||||
| Professional status | 0.004 | ||||||||||||
| Active | 2 | 6.5 | 10 | 11.8 | 16 | 15.8 | 6 | 20.7 | |||||
| Retired | 23 | 74.2 | 61 | 71.8 | 66 | 65.3 | 9 | 31.0 | |||||
| Other inactive | 6 | 19.4 | 14 | 16.5 | 19 | 18.8 | 14 | 48.3 | |||||
| Medical data | |||||||||||||
| Comorbidities potentially related to SHPT | 18 | 52.9 | 59 | 60.2 | 59 | 56.2 | 12 | 37.5 | 0.16 | ||||
| History of fracture | 5 | 14.7 | 22 | 22.4 | 24 | 22.9 | 2 | 6.3 | 0.14 | ||||
| Other comorbidities | |||||||||||||
| Diabetes | 6 | 17.6 | 20 | 20.4 | 31 | 29.5 | 9 | 28.1 | 0.33 | ||||
| High blood pressure | 15 | 44.1 | 40 | 40.8 | 50 | 47.6 | 19 | 59.4 | 0.32 | ||||
| Existence of a disability | 5 | 14.7 | 11 | 11.2 | 14 | 13.3 | 3 | 9.4 | 0.89 | ||||
| Cardiovascular disease(s) | 18 | 52.9 | 53 | 54.1 | 52 | 49.5 | 13 | 40.6 | 0.60 | ||||
| Charlson comorbidity index | 34 | 5.7 | 2.2 | 98 | 5.9 | 2.1 | 105 | 5.6 | 1.9 | 32 | 4.4 | 2.3 | 0.005 |
| History of kidney transplant | 2 | 5.9 | 6 | 6.1 | 9 | 8.6 | 3 | 9.4 | 0.88 | ||||
| Dialysis data | 0.52 | ||||||||||||
| Technique of dialysis | |||||||||||||
| Haemodialysis or hemodiafiltration | 33 | 97.1 | 90 | 91.8 | 93 | 88.6 | 29 | 90.6 | |||||
| Peritoneal dialysis | 1 | 2.9 | 8 | 8.2 | 12 | 11.4 | 3 | 9.4 | |||||
| Dialysis vintage (months) | 34 | 41.2 | 73.2 | 98 | 46.3 | 67.8 | 105 | 39.7 | 68.0 | 32 | 50.8 | 67.5 | 0.45 |
| Dialysate calcium concentration | 0.77 | ||||||||||||
| 1.25 mmol/L | 3 | 8.8 | 7 | 7.7 | 14 | 13.6 | 2 | 6.5 | |||||
| 1.50 mmol/L | 25 | 73.5 | 69 | 75.8 | 71 | 68.9 | 24 | 77.4 | |||||
| 1.60 mmol/L | 1 | 2.9 | 1 | 1.1 | 0 | 0.0 | 0 | 0.0 | |||||
| 1.75 mmol/L | 5 | 14.7 | 14 | 15.4 | 18 | 17.5 | 5 | 16.1 | |||||
| Use of ESA | 27 | 81.8 | 74 | 75.5 | 73 | 69.5 | 20 | 64.5 | 0.34 | ||||
Bold indicates statistical significance, p<0.05
*χ2 test or Fisher's exact test used to compare categorical variables. Analysis of variance or Wilcoxon's test used to compare continuous variables.
BMI, body mass index; ESA, erythropoiesis stimulating agent; PTH, parathyroid hormone; SHPT, secondary hyperparathyroidism.