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. 2017 Mar 20;7(3):e013076. doi: 10.1136/bmjopen-2016-013076

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Mean difference in change (95% CI) in HbA1c levels (%) after multifaceted care between intervention and control groups. Results are stratified by type of diabetes patient. IV, generic inverse variance method. The three studies including patients with prevalent diabetes has an intervention duration of 1-year. The methodology for calculating the difference in change between intervention and control group that Cleveringa et al.³³ have used (subtracting the HbA1c change over time for the control group from the change over time for the intervention group) was the opposite of that used by the other trials (subtracting the HbA1c change over time for the intervention group from the change over time for the control group). Since this would result in a misleading visual presentation of the findings from Cleveringa et al.,³³ we have recalculated their HbA1c results according to the methodology used by the other studies. The study of Webb et al.⁴³ had an intervention duration of one year and the study of Griffin et al.⁴⁶ combined the 5-year intervention data from all four Addition studies, including the five-year data from Webb et al.⁴³ The study including patients with newly detected diabetes had an intervention duration of six years.