Table 4.

Unadjusted and adjusted ORs of thrombotic events in patients with sickle cell trait (SCT), compared with patients without SCT, main and subgroup analyses

	Cases	Controls	OR*	Adjusted OR†	p Value
Main analysis
VTE
Non-carrier	125	1369	1.00	1.00	–
Carrier	55	406	1.55 (1.09 to 2.21)	1.78 (1.18 to 2.69)	0.006
DVT only
Non-carrier	83	841	1.00	1.00	–
Carrier	24	207	1.18 (0.71 to 1.95)	1.43 (0.79 to 2.59)	0.2
PE
Non-carrier	36	449	1.00	1.00	–
Carrier	26	170	2.09 (1.17 to 3.72)	2.27 (1.17 to 4.39)	0.011
Subgroup analysis
VTE definition included anticoagulant therapy, clinic attendance or death
Non-carrier	60	725	1.00	1.00	–
Carrier	36	223	2.20 (1.36 to 3.57)	2.71 (1.52 to 4.83)	0.001

*Matched by age and sex.

†Adjusted for age, sex, pregnancy, BMI, smoking status and ethnicity.