Table 3. Comparison of classification performance by six different methods (in %).
| Method | AD vs. NC |
MCI vs. NC |
pMCI vs. sMCI |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACC | SPE | SEN | AUC | ACC | SPE | SEN | AUC | ACC | SPE | SEN | AUC | |
| no FS (MRI only) | 88.3† | 81.9† | 92.2† | 94.1† | 72.5† | 80.7† | 42.9† | 72.0† | 68.4† | 59.4† | 75.9† | 73.2† |
| no FS (SNP only) | 77.3† | 75.3† | 80.6† | 85.3† | 74.8† | 83.2† | 36.1† | 74.1† | 73.1† | 67.7† | 80.8† | 79.2† |
| no FS (MRI + SNP) | 87.5† | 81.6† | 90.3† | 95.6† | 73.8† | 85.1† | 53.6† | 80.6† | 74.7† | 64.5† | 78.8† | 83.4† |
| Laplacian score33 | 87.7† | 83.3† | 90.9† | 94.3† | 73.9† | 85.1† | 53.0† | 81.4† | 76.6† | 65.2† | 78.8† | 77.6† |
| Pearson correlation34 | 87.8† | 84.9† | 89.7† | 94.6† | 73.7† | 83.6† | 53.3† | 79.1† | 77.1† | 66.9† | 82.5† | 78.6† |
| t-test31 | 87.8† | 84.5† | 90.3† | 94.2† | 73.1† | 84.4† | 53.1† | 80.4† | 76.0† | 65.5† | 78.3† | 78.1† |
| Fisher score32 | 88.8† | 85.9* | 91.4† | 94.9† | 73.6† | 84.9† | 57.4† | 82.1† | 76.7† | 68.0† | 83.8† | 78.4† |
| LASSO35 | 89.2† | 83.6† | 90.7† | 95.8† | 74.7† | 87.3 | 57.6 | 83.2† | 76.3† | 68.1† | 83.0† | 77.9† |
| RIML17 | 89.4† | 85.0* | 90.2† | 94.9† | 75.6† | 85.2† | 56.4† | 83.9† | 77.0† | 68.6† | 84.4* | 84.9† |
| HMFSS | 90.8† | 84.1† | 94.3† | 97.1* | 77.9* | 84.0† | 65.9† | 85.4† | 78.6† | 69.2* | 84.9* | 85.7† |
| ss-HMFSS | 92.4 | 86.0 | 95.9 | 97.4 | 80.1 | 85.5* | 67.7 | 87.2 | 80.8 | 71.5 | 85.4 | 88.3 |
Symbol † indicates p < 0.01 in the t-test as compared to the best method, and * means p < 0.05.