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. Author manuscript; available in PMC: 2017 Apr 30.
Published in final edited form as: Nat Chem Biol. 2016 Oct 31;13(1):38–45. doi: 10.1038/nchembio.2211

Figure 2. Multivariate analysis of small molecule kinase inhibitors on induced cytokine secretion.

Figure 2

(a) Principal component analysis of cytokine profiles differentiate secretion profiles for basal conditions (open data points) and TNFα–, IL–1α, or Poly(I:C)–activated SFs (colored data points). Solid red arrows illustrates activation by Poly(I:C)– and dotted arrow depicts the normalizing effect of lestaurtinib. (b) Ability of kinase inhibitors to prevent SF activation and restore the cytokine secretion profile to the pre–stimulus state. A value of 0 indicates no effect of the inhibitor and a value of 1 corresponds to complete normalization.

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