Table 2.
Stratified analysis (boys and girls) of adjusted associations for leptin methylation at four CpG sites and for overall mean as outcome and the three obesity-related measures as primary predictors
| Predictor | LEP methylation (dependent variable) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CpG-1 | CpG-2 | CpG-3 | CpG-4 | Mean | |||||||||||
| Boys β (SE) |
Girls β (SE) |
P § | Boys β (SE) |
Girls β (SE) |
P | Boys β (SE) |
Girls β (SE) |
P | Boys β (SE) |
Girls β (SE) |
P | Boys β (SE) |
Girls β (SE) |
P | |
| BMI-z | −0.765* (0.334) |
0.429 (0.371) |
0.02 | −0.341** (0.146) |
0.001 (0.162) |
0.11 | −0.651** (0.210) |
0.286 0.234 |
0.003 | −1.058** (0.364) |
0.190 (0.405) |
0.02 | −0.704** (0.225) |
0.227 (0.250) |
0.01 |
| WC-z | −1.064* (0.429) |
0.443 (0.456) |
0.01 | −0.515** (0.187) |
−0.079 (0.199) |
0.10 | −0.681* (0.272) |
0.341 (0.289) |
0.01 | −1.235** (0.469) |
0.273 (0.498) |
0.03 | −0.874** (0.289) |
0.245 (0.307) |
0.01 |
| PBF | −0.089* (0.036) |
0.057 (0.039) |
0.01 | −0.036* (0.016) |
0.005 (0.017) |
0.08 | −0.062** (0.022) |
0.030 (0.025) |
0.01 | −0.102* (0.039) |
−0.009 (0.044) |
0.11 | −0.072** (0.024) |
0.021 (0.027) |
0.01 |
Ordinary least squares regression models were adjusted for age and parental BMI
BMI-z body mass index z-score, WC-z waist circumference z-score, PBF percent body fat
P values: **0.001 ≤ P < 0.01; *0.01 ≤ P < 0.05
§ P value for interaction term between leptin methylation and sex