Fig. 4.

Profiling of histone modifiers in human serum samples. Cumulative analysis of a HDAC and b HAT activity assays done using the human serum of six healthy subjects and 24 cancer patients. With TSA—involves serum pre-treated with TSA for 10 min and without TSA—untreated samples. Graph showing the relative activity of HDACs in c CRC, d buccal, e tongue, f breast and glioblastoma samples. Statistical tests are done by using Student’s t test. *p < 0.05, **p < 0.01. g Table representing the subgrouping of all 24 human samples as per their HDAC activities. h Correlation between serum CEA levels and HDAC activity in six CRC samples. Highlighted samples show high CEA and HDAC levels