Table 2.
List of the 100 most dysregulated genes due to the 24h effect of BE
| Ensembl | Gene symbol | Description | Gene dysregulation at 24h |
|---|---|---|---|
| ENSG00000125257 | ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | Up-regulated |
| ENSG00000114770 | ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | Down-regulated |
| ENSG00000173208 | ABCD2 | ATP-binding cassette, sub-family D (ALD), member 2 | Up-regulated |
| ENSG00000151726 | ACSL1 | Acyl-CoA synthetase long-chain family member 1 | Down-regulated |
| ENSG00000135074 | ADAM19 | ADAM metallopeptidase domain 19 (meltrin beta) | Down-regulated |
| ENSG00000154027 | AK5 | Adenylate kinase 5 | Up-regulated |
| ENSG00000151150 | ANK3 | Ankyrin 3, node of Ranvier (ankyrin G) | Up-regulated |
| ENSG00000206560 | ANKRD28 | Ankyrin repeat domain 28 | Up-regulated |
| ENSG00000118520 | ARG1 | Arginase, liver | Down-regulated |
| ENSG00000196914 | ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | Up-regulated |
| ENSG00000156802 | ATAD2 | ATPase family, AAA domain containing 2 | Up-regulated |
| ENSG00000085224 | ATRX | Alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) | Up-regulated |
| ENSG00000023445 | BIRC3 | baculoviral IAP repeat-containing 3 | Up-regulated |
| ENSG00000102010 | BMX | BMX non-receptor tyrosine kinase | Down-regulated |
| ENSG00000136492 | BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | Up-regulated |
| ENSG00000197603 | C5orf42 | Chromosome 5 open reading frame 42 | Up-regulated |
| ENSG00000152495 | CAMK4 | Calcium/calmodulin-dependent protein kinase IV | Up-regulated |
| ENSG00000137812 | CASC5 | Cancer susceptibility candidate 5 | Up-regulated |
| ENSG00000138778 | CENPE | Centromere protein E, 312 kDa | Up-regulated |
| ENSG00000198707 | CEP290 | Centrosomal protein 290 kDa | Up-regulated |
| ENSG00000106034 | CPED1 | Cadherin-like and PC-esterase domain containing 1 | Up-regulated |
| ENSG00000103196 | CRISPLD2 | Cysteine-rich secretory protein LCCL domain containing 2 | Down-regulated |
| ENSG00000146122 | DAAM2 | Dishevelled associated activator of morphogenesis 2 | Down-regulated |
| ENSG00000035664 | DAPK2 | Death-associated protein kinase 2 | Down-regulated |
| ENSG00000137628 | DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | Up-regulated |
| ENSG00000174485 | DENND4A | DENN/MADD domain containing 4A | Up-regulated |
| ENSG00000135905 | DOCK10 | Dedicator of cytokinesis 10 | Up-regulated |
| ENSG00000147459 | DOCK5 | Dedicator of cytokinesis 5 | Down-regulated |
| ENSG00000088387 | DOCK9 | Dedicator of cytokinesis 9 | Up-regulated |
| ENSG00000178904 | DPY19L3 | Dpy-19-like 3 (C. elegans) | Down-regulated |
| ENSG00000134765 | DSC1 | Desmocollin 1 | Up-regulated |
| ENSG00000135636 | DYSF | Dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) | Down-regulated |
| ENSG00000198919 | DZIP3 | DAZ interacting protein 3, zinc finger | Up-regulated |
| ENSG00000102189 | EEA1 | Early endosome antigen 1 | Up-regulated |
| ENSG00000151491 | EPS8 | Epidermal growth factor receptor pathway substrate 8 | Up-regulated |
| ENSG00000089048 | ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | Up-regulated |
| ENSG00000198734 | F5 | Coagulation factor V (proaccelerin, labile factor) | Down-regulated |
| ENSG00000140525 | FANCI | Fanconi anemia, complementation group I | Up-regulated |
| ENSG00000138829 | FBN2 | Fibrillin 2 (congenital contractural arachnodactyly) | Down-regulated |
| ENSG00000139132 | FGD4 | FYVE, RhoGEF and PH domain containing 4 | Down-regulated |
| ENSG00000122025 | FLT3 | Fms-related tyrosine kinase 3 | Down-regulated |
| ENSG00000161791 | FMNL3 | Formin-like 3 | Up-regulated |
| ENSG00000073910 | FRY | Furry homolog (Drosophila) | Down-regulated |
| ENSG00000162654 | GBP4 | Guanylate binding protein 4 | Up-regulated |
| ENSG00000182885 | GPR97 | G protein-coupled receptor 97 | Down-regulated |
| ENSG00000106070 | GRB10 | Growth factor receptor-bound protein 10 | Down-regulated |
| ENSG00000084110 | HAL | Histidine ammonia-lyase | Down-regulated |
| ENSG00000120694 | HSPH1 | Heat shock 105/110 kDa protein 1 | Up-regulated |
| ENSG00000140443 | IGF1R | Insulin-like growth factor 1 receptor | Down-regulated |
| ENSG00000197081 | IGF2R | Insulin-like growth factor 2 receptor | Down-regulated |
| ENSG00000115604 | IL18R1 | Interleukin 18 receptor 1 | Down-regulated |
| ENSG00000115594 | IL1R1 | Interleukin 1 receptor, type I | Down-regulated |
| ENSG00000115590 | IL1R2 | Interleukin 1 receptor, type II | Down-regulated |
| ENSG00000109452 | INPP4B | Inositol polyphosphate-4-phosphatase, type II, 105 kDa | Up-regulated |
| ENSG00000102445 | KIAA0226L | KIAA0226-like | Down-regulated |
| ENSG00000137261 | KIAA0319 | KIAA0319 | Down-regulated |
| ENSG00000110318 | KIAA1377 | KIAA1377 | Up-regulated |
| ENSG00000054523 | KIF1B | Kinesin family member 1B | Down-regulated |
| ENSG00000138182 | KIF20B | Kinesin family member 20B | Up-regulated |
| ENSG00000139116 | KIF21A | Kinesin family member 21A | Up-regulated |
| ENSG00000068796 | KIF2A | Kinesin heavy chain member 2A | Up-regulated |
| ENSG00000184445 | KNTC1 | Kinetochore associated 1 | Up-regulated |
| ENSG00000126777 | KTN1 | Kinectin 1 (kinesin receptor) | Up-regulated |
| ENSG00000123384 | LRP1 | Low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) | Down-regulated |
| ENSG00000186205 | MARC1 | Mitochondrial amidoxime reducing component 1 | Down-regulated |
| ENSG00000257335 | MGAM | Maltase-glucoamylase (alpha-glucosidase) | Down-regulated |
| ENSG00000171843 | MLLT3 | Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | Up-regulated |
| ENSG00000196549 | MME | Membrane metallo-endopeptidase | Down-regulated |
| ENSG00000100985 | MMP9 | Matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase) | Down-regulated |
| ENSG00000051825 | MPHOSPH9 | M-phase phosphoprotein 9 | Up-regulated |
| ENSG00000138119 | MYOF | Myoferlin | Up-regulated |
| ENSG00000049759 | NEDD4L | Neural precursor cell expressed, developmentally down-regulated 4-like | Up-regulated |
| ENSG00000184613 | NELL2 | NEL-like 2 (chicken) | Up-regulated |
| ENSG00000173145 | NOC3L | Nucleolar complex associated 3 homolog (S. cerevisiae) | Up-regulated |
| ENSG00000179299 | NSUN7 | NOL1/NOP2/Sun domain family, member 7 | Down-regulated |
| ENSG00000111581 | NUP107 | Nucleoporin 107 kDa | Up-regulated |
| ENSG00000159339 | PADI4 | Peptidyl arginine deiminase, type IV | Down-regulated |
| ENSG00000123836 | PFKFB2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | Down-regulated |
| ENSG00000075651 | PLD1 | Phospholipase D1, phosphatidylcholine-specific | Down-regulated |
| ENSG00000101868 | POLA1 | Polymerase (DNA directed), alpha 1 | Up-regulated |
| ENSG00000080839 | RBL1 | Retinoblastoma-like 1 (p107) | Up-regulated |
| ENSG00000257743 | RP11-1220K2.2 | Putative inactive maltase-glucoamylase-like protein LOC93432 | Down-regulated |
| ENSG00000226891 | RP11-182I10.3 | Uncharacterized LOC101927084 | Down-regulated |
| ENSG00000258476 | RP11-76E17.3 | NA | Down-regulated |
| ENSG00000140386 | SCAPER | S phase cyclin A-associated protein in the ER | Up-regulated |
| ENSG00000018280 | SLC11A1 | Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 | Down-regulated |
| ENSG00000140090 | SLC24A4 | Solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 | Down-regulated |
| ENSG00000112053 | SLC26A8 | Solute carrier family 26, member 8 | Down-regulated |
| ENSG00000157800 | SLC37A3 | Solute carrier family 37 (glycerol-3-phosphate transporter), member 3 | Down-regulated |
| ENSG00000136824 | SMC2 | Structural maintenance of chromosomes 2 | Up-regulated |
| ENSG00000163029 | SMC6 | Structural maintenance of chromosomes 6 | Up-regulated |
| ENSG00000009694 | TENM1 | Teneurin transmembrane protein 1 | Down-regulated |
| ENSG00000169902 | TPST1 | Tyrosylprotein sulfotransferase 1 | Down-regulated |
| ENSG00000198677 | TTC37 | Tetratricopeptide repeat domain 37 | Up-regulated |
| ENSG00000155657 | TTN | Titin | Up-regulated |
| ENSG00000120800 | UTP20 | UTP20, small subunit (SSU) processome component, homolog (yeast) | Up-regulated |
| ENSG00000197969 | VPS13A | Vacuolar protein sorting 13 homolog A (S. cerevisiae) | Up-regulated |
| ENSG00000163625 | WDFY3 | WD repeat and FYVE domain containing 3 | Down-regulated |
| ENSG00000213799 | ZNF845 | Zinc finger protein 845 | Up-regulated |
| ENSG00000167232 | ZNF91 | Zinc finger protein 91 | Up-regulated |
Information includes the Ensembl code, the gene symbol, description and sign of dysregulation. For convenience, the genes are ordered alphabetically