Table 2. The binding of conjugates of aminoadamantanes with carbazole derivatives C-1 and C-2 (Fig. 1) to МК-801 and ifenprodil binding sites of NMDA receptor.

Compounds				Binding characteristics of compounds
No	R	R1	R2	% of [3H]МК-801 blockade at 100 μM of compound	[3H]МК-801, IC50, μM	% of [3H]ifenprodil blockade at 100 μM of compound	[3H]ifenprodil, IC50, μM
C-1a	H	H	H	83.5 ± 7.6	75.3 ± 6.9	74.2 ± 6.8	8.2 ± 0.8
C-1b	H	H	CH3	68.5 ± 5.4	59.1 ± 4.9	76.2 ± 6.6	21.3 ± 1.9
C-1c	Br	Br	H	55.1 ± 4.9	79.4 ± 7.5	85.3 ± 7.6	22.9 ± 1.8
C-1d	Br	Br	CH3	33.8 ± 3.5	>100	67.6 ± 5.8	31.5 ± 3.3
C-1e	CI	CI	H	28.3 ± 1.8	>100	70.6 ± 7.1	21.8 ± 1.8
C-1f	CI	CI	CH3	72.8 ± 6.8	22.4 ± 2.1	71.4 ± 5.7	14.6 ± 1.5
C-2a	H	H	H	32.3 ± 3.0	>100	71.6 ± 8.3	82.5 ± 9.3
C-2b	H	H	CH3	62.2 ± 6.3	14.2 ± 2.3	58.4 ± 5.6	65.5 ± 6.1
C-2c	CH3	H	H	0 ± 2.0	>100	51.6 ± 7.2	98.4 ± 6.9
C-2d	CH3	H	CH3	18.3 ± 2.0	>100	31.4 ± 3.1	>100
C-2e	CH3	CH3	H	29.3 ± 6.4	>100	67.2 ± 7.3	8.1 ± 1.7
C-2f	CH3	CH3	CH3	65.2 ± 5.3	19.5 ± 1.6	71.4 ± 6.5	10.3 ± 1.9
C-2g	F	H	H	0 ± 2.0	>100	48.4 ± 5.2	>100
C-2h	F	H	CH3	88.5 ± 9.0	27.4 ± 4.1	87.2 ± 7.3	10.4 ± 2.9
Memantine				100	1.36 ± 0.086	11.2 ± 1.1	>100
Amantadine				57.2 ± 5.5	35.5 ± 3.2	44.6 ± 4.6	>100