Table 3. Influence of conjugates of aminoadamantanes with carbazole derivatives C-1 and C-2 (Fig. 1) on tubulin polymerization.

Compounds				(dA355/dt)max, % (at 100 μM of compound)
No	R	R1	R2	100 ± 14
C-1a	H	H	H	192 ± 14
C-1b	H	H	CH3	249 ± 16
C-1c	Br	Br	H	124 ± 17
C-1d	Br	Br	CH3	104 ± 24
C-1e	CI	CI	H	100 ± 8
C-1f	CI	CI	CH3	101 ± 15
C-2a	H	H	H	155 ± 22
C-2b	H	H	CH3	127 ± 10
C-2c	CH3	H	H	152 ± 12
C-2d	CH3	H	CH3	182 ± 16
C-2e	CH3	CH3	H	158 ± 19
C-2f	CH3	CH3	CH3	133 ± 14
C-2g	F	H	H	164 ± 18
C-2h	F	H	CH3	330 ± 40
Memantine				89 ± 7
Amantadine				98 ± 16
Carbazole				123 ± 12
Paclitaxel (5 μM)				487 ± 32

Data presented as percent of maximum rate of 355 nm absorbance increase due to microtubules assembly. 100% - maximum rate of 355 nm absorbance in control probe with only vehicle (10% of DMSO).