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. 2017 Mar 30;7:45623. doi: 10.1038/srep45623

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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IPA was performed using 94 ECM proteins identified in our secretome analysis to determine the significant protein networks. Hierarchical model showing TGFβ1 as a major hub protein, interacting with or regulating expression of several other proteins in the network. Bold arrows show direct regulation, bold lines show direct interactions while dotted lines represent indirect interactions among proteins shown in the network.