Table 2.
Staining results and correlation analysis.
| H3K9ac | H3K4me3 (Cytoplasmic) | H3K4me3 (Nuclear) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Median IRS (+/−SD) | % | p (NPAR) | ρ | Median IRS (+/−SD) | % | p (NPAR) | ρ | Median IRS (+/−SD) | % | p (NPAR) | ρ | |
| Histology | ||||||||||||
| SCC | 4 (+/−3.45) | 40.10% | 0.013 | - | 0 (+/−2.67) | 57.40% | 0.296 | - | 8 (+/−3.56) | 32.20% | 0.603 | - |
| Adeno-Ca | 8 (+/−3.78) | 31.30% | 0 (+/−3.35) | 52.10% | 8 (+/−3.58) | 27.10% | ||||||
| Grade | ||||||||||||
| G1 | 8 (+/−3.51) | 31.00% | 0.004 | −0.209 (p = 0.001) | 0 (+/−2.94) | 57.10% | 0.197 | 0.082 (p > 0.05) | 8 (+/−3.66) | 28.60% | 0.917 | −0.017 (p > 0.05) |
| G2 | 4 (+/−3.57) | 35.00% | 0 (+/−3.08) | 52.40% | 8 (+/−3.59) | 31.50% | ||||||
| G3 | 4 (+/−3.26) | 41.00% | 0 (+/−2.24) | 62.80% | 8 (+/−3.55) | 33.30% | ||||||
| pN | ||||||||||||
| N− | 4 (+/−3.55) | 86.10% | 0.001 | −0.236 (p = 0.000) | 0 (+/−3.02) | 57.00% | 0.981 | −0.001 (p > 0.05) | 8 (+/−3.50) | 32.50% | 0.695 | 0.025 (p > 0.05) |
| N+ | 4 (+/−3.33) | 66.00% | 0 (+/−2.43) | 55.70% | 8 (+/−3.69) | 28.90% | ||||||
| pT | ||||||||||||
| T1 | 4 (+/−3.52) | 30.90% | 0.035 | −0.149 (p = 0.019) | 0 (+/−2.34) | 69.10% | 0.002 | 0.191 (p = 0.003) | 8 (+/−3.49) | 30.00% | 0.171 | 0.081 (p > 0.05) |
| T2/3/4 | 4 (+/−3.49) | 40.90% | 2 (+/−2.93) | 3.60% | 8 (+/−3.60) | 32.10% | ||||||
| FIGO | ||||||||||||
| I | 8 (+/−3.91) | 26.60% | 0.016 | −0.192 (p = 0.016) | 0 (+/−2.45) | 64.10% | 0.324 | 0.070 (p = 0.384) | 8 (+/−3.37) | 32.80% | 0.862 | −0.005 (p = 0.948) |
| II+ | 4 (+/−3.44) | 23.90% | 2 (+/−2.66) | 5.40% | 8 (+/−3.67) | 30.40% | ||||||
| p16 | - | - | - | 0.047 (p > 0.05) | - | - | - | 0.009 (p > 0.05) | - | - | - | 0.144 (p = 0.027) |
SD = standard deviation; % = percentage of the subgroup with median IRS; NPAR = non-parametric test; p = p-value; ρ = correlation coefficient; SCC = squamous cell carcinoma, pT = tumor size, FIGO = TNM classification and the International Federation of Gynecology and Obstetrics.