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Netrin-1 functions in the developing spinal cord. Netrin-1 (pink) secreted by cells in the floor plate diffuses to the spinal cord tissue and forms a gradient concentration to attract dorsoventral projecting commissural axons (red) which express DCC, Neogenin or DSCAM. Oligodendrocyte precursor cells (blue) express both DCC and Unc5A [15] are repelled by Netrin-1 and migrate away from the ventral ventricular zone.
