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. 2017 Feb 24;18(3):491. doi: 10.3390/ijms18030491

Figure 3.

Figure 3

Schematic comparing the distinct models of Netrin-1/Neogenin and Netrin-1/DCC interaction. 0: site 0; 1: site 1; and 2: site 2. (A) Netrin-1 and Neogenin form a 2:2 ligand–receptor complex. Two Netrin-1 molecules form a head-to-head X-shaped dimer and interact with each other via the Netrin-1 EGF2 interfaces. (B) In Xu’s Netrin-1 and DCC binding model [43], the Netrin-1 LN domain interacts with the DCC FNIII4 domain, the Netrin-1 EGF3 domain interacts with the DCC FNIII5 domain, leading to Netrin-1 and DCC forming a continuous DCC-Netrin-1-DCC-Netrin-1-DCC assembly and the EGF2 domain of Netrin-1 is free for Unc5A–D binding. (C) In Finci’s Netrin-1 and DCC binding model [44], one Netrin-1 molecule still binds two DCC receptors but the EGF2 domain is engaged with the DCC FNIII5 and FNIII6 domains.