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. 2017 Feb 27;18(3):513. doi: 10.3390/ijms18030513

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Selective miRNAs in MM-MVs that confer caspase-3-induced apoptosis in HK-2 cells. (A) Comparative analysis of renal-pathogenic miRNAs between RPMI8226-MVs and K562-MVs. RPMI8226-MVs were enriched in more highly-expressed renal-pathogenic miRNAs than did K562-MVs; (B) The heatmap of renal-protective miRNAs in RPMI8226-MVs and K562-MVs showed low levels of renal-protective miRNAs in the two types of MVs; (C,D) A schematic illustration representing MM-MV-packed miRNAs, including renal-pathogenic (C) and –protective miRNAs (D), and potential targets involved in regulation of caspase-3 in HK-2 cells. Yellow triangles: miRNAs relatively highly represented in RPMI8226-MVs. Green ellipse: caspase 3 gene. Blue rectangles: regulators interacted with hub genes and targeted by miRNAs; (E) Evaluation of the levels of the miRNAs involved in the regulation network and differentially expressed between RPMI8226-MVs and K562-MVs, using real-time PCR (* p < 0.01, ** p < 0.05).

Selective miRNAs in MM-MVs that confer caspase-3-induced apoptosis in HK-2 cells. (A) Comparative analysis of renal-pathogenic miRNAs between RPMI8226-MVs and K562-MVs. RPMI8226-MVs were enriched in more highly-expressed renal-pathogenic miRNAs than did K562-MVs; (B) The heatmap of renal-protective miRNAs in RPMI8226-MVs and K562-MVs showed low levels of renal-protective miRNAs in the two types of MVs; (C,D) A schematic illustration representing MM-MV-packed miRNAs, including renal-pathogenic (C) and –protective miRNAs (D), and potential targets involved in regulation of caspase-3 in HK-2 cells. Yellow triangles: miRNAs relatively highly represented in RPMI8226-MVs. Green ellipse: caspase 3 gene. Blue rectangles: regulators interacted with hub genes and targeted by miRNAs; (E) Evaluation of the levels of the miRNAs involved in the regulation network and differentially expressed between RPMI8226-MVs and K562-MVs, using real-time PCR (* p < 0.01, ** p < 0.05).