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CD138+ cirMV counts positively correlate with renal impairment. The enrolled 61 de novo patients with MM were divided into two groups according the levels of SCr (group 1, SCr < 2 mg/dL, n = 45; group 2 SCr ≥ 2 mg/dL, n = 16). The levels of CD138+ cirMVs were significantly higher in group 1 than in group 2 (A, p = 0.0138), and the ROC value for using CD138+ cirMV counts to diagnose RI in de novo patients with MM was 0.731 (B).
