Table 3.
Cox-regression multivariate analysis for factors associated with survival.
| Model | ER HR (95% CI) | PR HR (95% CI) | ER + PR HR (95% CI) |
|---|---|---|---|
| Model 1 a | n = 172 | n = 172 | |
| Marker absent | 1.0 (Reference) | 1.0 (Reference) | Not performed |
| Marker focal | 0.230 (0.0713–0.685) | 0.256 (0.079–0.780) | |
| Marker diffuse | 0.160 (0.07–0.403) | 0.209 (0.089–0.517) | |
| p | 0.0003 | 0.0018 | |
| Model 2 a | n = 172 | n = 172 | n = 160 * |
| Markers absent | 1.0 (Reference) | 1.0 (Reference) | 1.0 (Reference) |
| Markers present | 0.175 (0.076–0.425) | 0.218 (0.096–0.527) | 0.123 (0.066–0.428) |
| p | 0.0002 | 0.0011 | 0.0001 |
| Model 3 b Stage I/II | n = 149 | n = 149 | n = 138 * |
| Markers absent | 1.0 (Reference) | 1.0 (Reference) | 1.0 (Reference) |
| Markers present | 0.351 (0.137–0.976) | 0.400 (0.151–1.176) | 0.257 (0.079–0.946) |
| p | 0.0452 | 0.0932 | 0.0417 |
a adjusted for age, center, stage (missing stage excluded), residual disease (missing data as separate category), histological grade; b adjusted for age, center, residual disease (missing data as separate category), histological grade; * cases with either only ER or only PR expression were excluded.