Table 1.

Summary of responses to ET_A receptor antagonists in animal models of preeclampsia.

Animal Model	Response to ETA Receptor Antagonist	References
RUPP	↓ MAP, ↓ UARI	[18,28]
sFlt-1 infusion	↓ MAP	[8]
TNF-α infusion	↓ MAP	[7]
AT1-AA infusion	↓ MAP	[19]

RUPP, reduced uterine perfusion pressure; sFlt-1, soluble fms-like tyrosine kinase-1; TNF-α, tumor necrosis factor-α; AT1-AA, angiotensin II receptor type 1 autoantibody; ETA, endothelin receptor type A; MAP, mean arterial pressure; UARI, uterine artery resistance index; ↓, reduced.