Table 1.
Expression of autophagy-related proteins according to histologic thyroid cancer subtype.
| Parameters | Total n = 555 (%) | PTC n = 342 (%) | FC n = 112 (%) | MC n = 70 (%) | PDC n = 23 (%) | AC n = 8 (%) | p-Value |
|---|---|---|---|---|---|---|---|
| LC3A (T) | <0.001 | ||||||
| Negative | 421 (75.9) | 294 (86.0) | 99 (88.4) | 0 (0.0) | 20 (87.0) | 8 (100.0) | |
| Positive | 134 (24.1) | 48 (14.0) | 13 (11.6) | 70 (100.0) | 3 (13.0) | 0 (0.0) | |
| LC3A (S) | <0.001 | ||||||
| Negative | 359 (64.7) | 167 (48.8) | 99 (88.4) | 70 (100.0) | 21 (91.3) | 2 (25.0) | |
| Positive | 196 (35.3) | 175 (51.2) | 13 (11.6) | 0 (0.0) | 2 (8.7) | 6 (75.0) | |
| LC3B | <0.001 | ||||||
| Negative | 283 (51.0) | 146 (42.7) | 99 (88.4) | 14 (20.0) | 20 (87.0) | 4 (50.0) | |
| Positive | 272 (49.0) | 196 (57.3) | 13 (11.6) | 56 (80.0) | 3 (13.0) | 4 (50.0) | |
| P62 | 0.220 | ||||||
| Negative | 221 (39.8) | 134 (39.2) | 53 (47.3) | 24 (34.3) | 6 (26.1) | 4 (50.0) | |
| Positive | 334 (60.2) | 208 (60.8) | 59 (52.7) | 46 (65.7) | 17 (73.9) | 4 (50.0) | |
| BNIP-3 | 0.016 | ||||||
| Negative | 494 (89.0) | 297 (86.8) | 100 (89.3) | 70 (100.0) | 19 (82.6) | 8 (100.0) | |
| Positive | 61 (11.0) | 45 (13.2) | 12 (10.7) | 0 (0.0) | 4 (17.4) | 0 (0.0) |
PTC: papillary thyroid carcinoma; FC: follicular carcinoma; MC: medullary carcinoma; PDC: poorly differentiated carcinoma; AC: anaplastic carcinoma; T: tumoral; S: stromal. Bold indicates statistically significant (p < 0.05).