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Antiproliferative effect of anticancer drugs on Calu-6 and rCalu-6 cells. The tesistance index (RI) is reported as IC50 rCalu-6/IC50 Calu-6.
| Drug | IC50 (μM) | r/Calu-6 | p-Value (Calu-6 vs. rCalu-6) |
|---|---|---|---|
| Calu-6 | |||
| 5-FU | 4.5 ± 0.08 | 52.3 ± 0.02 (RI = 11.7X) | <0.01 |
| 5′-DFUR | 8.35 ± 0.06 | 56.7 ± 0.03 (RI = 7X) | <0.05 |
| L-OHP | 5 ± 0.07 | 50 ± 0.03 (RI = 10X) | <0.01 |
| Cisplatin | 10 ± 0.02 | 60 ± 0.05 (RI = 6X) | <0.01 |
