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. 2017 Mar 4;18(3):551. doi: 10.3390/ijms18030551

Figure 1.

Figure 1

Effect of Atremorine (AT) treatment against dopaminergic degeneration. Comparative photomicrographs of tyrosine hydroxylase (TH) immunoreactivity were taken in the substantia nigra (SN) of mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity, untreated (E) and treated with l-DOPA (C,D) or Atremorine (A,B). Note the remarkable effect of Atremorine (A,B) in reversing the neurotoxic effect of MPTP on dopaminergic neurons. (A–F) Atremorine; (J–L) Atremorine + L-DOPA; (M–O) Untreated; (P–R) Control + Atremorine. Scale bar: 100 µm. Adapted with permission from Carrera et al. [101].