Table 3.

Number of significant gene expression changes per category representative of toxicological pathways for each drug and each human liver experiment.

Gene Categories	APAP			DCF			MMI			TBF
	HL869	HL870	HL871	HL869	HL870	HL871	HL869	HL870	HL871	HL869	HL870	HL871
Metabolism	3	3	3	5	3	5	2	4	2	4	2	3
Oxidative Stress	3	4	4	4	4	3	0	1	3	7	5	4
Mitochondria Energy	2	3	2	1	1	1	0	3	1	0	3	1
Heat Shock and ER Stress	6	4	7	11	11	14	1	4	4	4	4	4
Fatty Acid Metabolism	4	3	3	6	3	3	0	2	0	5	3	1
Steatosis, Cholestasis, Phospholipidosis	8	9	9	14	9	10	1	10	3	12	3	2
DNA damage, repair	0	0	2	2	2	2	0	5	3	1	3	3
Apoptosis	1	1	5	7	6	8	0	2	2	2	3	2
Necrosis	0	2	7	0	0	1	0	0	1	2	0	1
Immune Response, Inflammation	0	2	4	3	4	4	0	4	2	1	1	3
Total	27	31	46	52	43	51	4	35	21	34	27	24
Gene Categories	CBZ			ETM			DTL			CSA
	HL869	HL870	HL871	HL869	HL870	HL871	HL869	HL870	HL871	HL869	HL870	HL871
Metabolism	4	3	1	1	0	0	3	4	2	0	1	1
Oxidative Stress	5	4	0	1	2	6	6	0	3	3	3	3
Mitochondria Energy	0	2	4	2	2	1	2	2	0	1	2	0
Heat Shock and ER Stress	3	5	2	2	5	8	5	9	1	11	12	4
Fatty Acid Metabolism	3	4	4	5	5	2	21	1	8	2	0	2
Steatosis, Cholestasis, Phospholipidosis	7	4	4	8	4	3	11	4	10	9	8	4
DNA damage, repair	0	1	1	0	1	3	4	2	4	3	3	5
Apoptosis	2	1	4	0	1	6	4	2	4	5	2	5
Necrosis	0	0	1	1	3	2	1	1	1	2	2	1
Immune Response, Inflammation	0	3	5	1	4	4	1	3	3	4	4	4
Total	24	27	26	21	27	35	58	28	36	40	37	29