Table 5.

Summary of oxidative stress and mitochondria function markers, ATP and GSH levels (↑ = increase, ↓ = decrease) plus gene expression pathways affected by each drug. Gene categories listed in each column represent the percent of total gene expression changes by each drug.

Drug	Dose	Human Liver Slice ATP Levels 72 h	Human Liver Slice GSH Levels 72 h	Oxidative Stress, Mitochondria Energy, Heat Shock/ER Stress, 48 h	DNA Damage/Repair, Apoptosis, Necrosis, Inflammation & Immune, 48 h	FA Metabolism, Steatosis, Cholestasis, Inflammation Immune, 48 h
APAP	1 mM	↓ 16%–25%, n = 3	↑ 21%–39%, n = 3	34%	23%	40%
DCF	1 mM	↓ 50%–85%, n = 3	↓ 30%–50%, n = 2	34%	27%	38%
ETM	100 μM	↓ 20%, n = 2	↑ 13%–24%, n = 2	35%	31%	43%
DTL	10 μM	↓ 19%, n = 3	↑ 31%–68%, n = 2	23%	25%	51%
CSA	10 μM	↓ 17%–30%, n = 2	↓ 30%, n = 1	37%	38%	35%
MMI	500 μM	↓ 14%–33%, n = 2	↑ 30%–49%, n = 3	28%	32%	37%
TBF	100 μM	↓ 25%, n = 1; ↑ 30%, n = 1	↑ 20%–39%, n = 2	36%	25%	35%
CBZ	100 μM	↓ 17%, n = 1	↑ 20%–30%, n = 2	33%	23%	44%