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Effects of Zn deficiency and supplementation on T2DM-induced downregulation of Nrf2 and downstream genes in db/db mice. The expression levels of Nrf2 protein and downstream factors, such as catalase and NAD(P)H dehydrogenase 1( NQO-1), were examined by Western blot (A) and RT-PCR (B). Data were presented as mean ± SD (n = 4–7, details in Figure 1). *, p < 0.05 vs. WT group; #, p < 0.05 vs. db/ZN group.
