Figure 2.

Strategies to increase adiponectin signaling in AD neurons. Peripherally, adiponectin expression from the liver, adipocytes and muscle can be increased by administering PPARγ agonist (e.g., pioglitazone) and physical exercise induction. Physical exercise can also increase the transport of low molecular weight nd trimeric adiponectin across the blood-brain barrier (BBB). Administration of adipoR agonists and LMW adiponectin acts on AdipoR1 in neurons and microglia to exert neuroprotection. Green arrow denotes increase, arrows and dash arrows denote promotion, T-bars denote inhibition.