This 60-year-old female had a mild keloid that was treated by 1064 nm long-pulsed Nd:YAG laser. Long-pulsed 1064 nm Nd:YAG laser was used at the following settings: 5 mm spot diameter, 75 J/cm2, 25 msec, and 2 Hz. After 1 year of treatment, the scar had almost disappeared. The known target of long-pulsed Nd:YAG lasers is the blood vessels. Thus, we speculate that laser therapy largely treats pathological scars by decreasing blood vessel numbers, thereby inhibiting the inflammatory signals coming from the blood vessels. (a) Pretreatment view; (b) after 10 months of treatment; and (c) after 16 months of treatment.